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(813) 769-8810

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Limitations of Other Testing Methods

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Limitations of Other Testing Methods

lab14

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Other Methods

LC-UV

  • Limited specificity
  • Variability of UV spectra
  • Many compounds have little to no UV absorbance

GC-MS

  • Increase sensitivity and specificity (Compared to LC-UV)
  • Cannot detect non-volatile, polar, and thermally labile compounds
  • Requires lengthy sample preparation (hydrolysis/derivatization)
  • High reproducibility of generated mass spectra

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Long-Standing Issues With GCMS

Until recently, GCMS was the “Gold Standard” for urine drug confirmation testing, however, there have been several long-standing issues with GCMS recently overcome with the advancement of LCMSMS technology applied to this field. These issues have been solved:

  • Sample prep is extensive and expensive
  • Does not cover many compounds – especially new drugs
  • Detection limits are not sufficient for many new more potent drugs
  • Cannot separate similar drugs easily
  • Cannot detect low concentration drugs in the presence of much higher concentrations

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Contact Us

If you would like to inquire about our products and services, check prices or place an order, contact an Office Representative. All requests made during non-business hours will be responded to as early as possible the next business day.

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